In brief: double-blinded research at the University of Reading (UK) with about 470 adults —18–58 years of age (mean 23.0, median 20), roughly 80% female— randomly assigned for one month to placebo or to B12 as methylcobalmin (1000 μg i.e., one mg ) or to B6 as pyroxidine Pyridoxine- Wik- Redirected fr Pyroxidine hydrochloride (100mg) FOUND
Results
Vitamin B6 supplementation reduced self-reported anxiety and induced a trend towards reduced depression, as well as increased surround suppression of visual contrast detection, but did not reliably influence the other outcome measures. Vitamin B12 supplementation produced trends towards changes in anxiety and visual processing.
Conclusions
Our results suggest that high-dose Vitamin B6 supplementation increases inhibitory GABAergic neural influences, which is consistent with its known role in the synthesis of GABA [gamma-aminobutyric acid].